Semuliki National Park has variety of Fauna; over 53 mammal species of which 11 mammals are endemic to the park. Uganda Wildlife safari game include; elephants, buffalos, chimpanzees, civets, hippos, grey cheeked manga bey, Mona monkeys, forest buffalo, bay duiker, Beecroft’s flying squirrel, pygmy flying squirrel, little collared fruit bat, water chevrotain, target rats, olive baboons, gentle blue monkeys, bush babies among the many.

Of the 1047 birds recorded in Uganda, Semuliki hosts over 435 bird species (43%) where over 40 species are Congolese and endemic to the park hence christening it the True birders Haven for those interested in Uganda birding safaris.

Some of these birds include; the Albertine Rift Endemics such as the Dwarf Honey guide and Purple-breasted Sun-bird can occasionally be sighted.

Also, species with very limited ranges such as White-tailed Hornbill, Capuchin Babbler, Blue-headed Crested Flycatcher and the orange weaver occur in the park. The park also has about 300 butterfly species.

With all these wildlife species found in the forest, it makes it suitable for Uganda wildlife safaris. Sempaya Ntandi Road This 6 km section of public road runs along one of the loveliest tracts of forest in Uganda and provides good views of birds and monkeys high up in the forest canopy.

Birding walks take place in Sempaya as well as night hikes deep into the forest.